購買 2-FDCK 線上 | 批發 2-FDCK
購買 2-FDCK online at chemsaxis. 2-FDCK 或 2-Fluorodeschloroketatamine is a new designer drug of the ketamine class and is dissociatives. 2-FDCK produced in modern laboratories in compliance with all standards.
價格：
2-FDCK 10g 160 $ 加入購物車
2-FDCK 100g 690 $ 加入購物車 免費運送!
2-FDCK 500g 1590 $ 加入購物車 免費運送!
2-FDCK 1 kg 2190 $ 加入購物車 免費運送!
2-FDCK 5 kg 4590 $ 加入購物車 免費運送!
2-FDCK 10 kg 6590 $ 加入購物車 免費運送!
2-FDCK 是一種專門設計用於研究和法醫应用的新型新精神活性物質。.
毒理學與生理學特性 2-FDCK 尚未被研究.
儲存條件：存放在陰涼乾燥處。.
儲存期限：在適當的儲存條件下可達 2 年。.
非供人類食用.
| 同義詞 | 2-Fluoroketamine, Fluoroketamine, 2-FK, 2-FDCK, 2-Fl-2′-Oxo-PCM |
|---|---|
| 國際純化學與應用化學聯合會 | (R/S)-2-(2-fluorophenyl)-2-(methylamino)cyclohexanone |
| 公式 | C13H16FNO |
| 分子量 | 221.28 g·mol−1 |
| CAS | 111982-50-4 |
| 外觀 | 結晶質 |
| 純度 | > 99 % |
| 限制 | 不 |
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2-Fluorodeschloroketamine （也稱為 2′-Fl-2-Oxo-PCM, fluoroketamine, ，及 2-FDCK) is a dissociative anesthetic 相關的 ketamine. Its sale and use as a 設計毒品 has been reported in various countries. It is an analogue of ketamine where the chlorine group has been replaced by fluorine. Due to its recent emergence, the pharmacological specifics of the compound are mostly unclear, but effects are reported to be similar to its parent compound, ketamine.
歷史
The synthesis of 2-FDCK was first described in a 2013 paper as part of a larger effort to synthesize and evaluate new anesthetic drugs based on ketamine and its analogues. Ketamine itself was first introduced in 1964 and was approved for clinical use in 1970. Since then it has become one of the most important and applicable general anesthetics as well as a popular recreational drug.
The use of 2-FDCK as a research chemical has been reported in various countries. Many of these new psychoactive substances (NPS) appear on the drug market in order to circumvent existing drug policies. 2-FDCK was first formally notified by the EMCDDA in 2016, alongside 65 other new substances. Due to its recent appearance, little research has been done on the compound so far.
In January 2023, Israeli Biotech company “Clearmind Medicine Inc.” announced the successful completion of a preclinical study examining 2-FDCK in a rat model of depression, with the compound outperforming ketamine in longevity of antidepressant effect.
化學
Structure
The full chemical name of 2-FDCK is 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one.
2-FDCK belongs to a class of compounds called arylcyclohexylamines which contains various other drugs such as PCP 與 ketamine. Their general structure consists of a cyclohexylamine unit with an aryl group attached to the same carbon as the 胺. 2-FDCK has an o-fluorophenyl group as an aryl substituent and the amine group is methylated. The cyclohexyl ring features a ketone group next to the amine position.
The chemical structure of 2-FDCK differs from ketamine only in that there is a fluorine atom attached to the phenyl group. Ketamine has a chlorine atom in that position.
Synthesis
2-FDCK can be synthesized in a five-step reaction process. First 2-fluorobenzonitrile reacts with the Grignard reagent cyclopentyl magnesium bromide followed by a bromination reaction to obtain α-bromocyclopentyl-(2-fluorophenyl)-ketone. The reaction of the obtained ketone with methylamine at −40 °C then results in the formation of α-hydroxycyclopentyl-(2-fluorophenyl)-N-methylamine. Finally, the five-membered ring cyclopentanol form is expanded to a cyclohexylketone form by a thermal rearrangement reaction. HCl is used to create a water-soluble HCl salt of 2-FDCK.
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