Kopen 2-FDCK online | Groothandel 2-FDCK
Kopen 2-FDCK online at chemsaxis. 2-FDCK of 2-Fluorodeschloroketatamine is a new designer drug of the ketamine class and is dissociatives. 2-FDCK produced in modern laboratories in compliance with all standards.
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2-FDCK 10g 160 $ Toevoegen aan winkelwagen
2-FDCK 100g 690 $ Toevoegen aan winkelwagen Gratis verzending!
2-FDCK 500g 1590 $ Toevoegen aan winkelwagen Gratis verzending!
2-FDCK 1 kg 2190 $ Toevoegen aan winkelwagen Gratis verzending!
2-FDCK 5 kg 4590 $ Toevoegen aan winkelwagen Gratis verzending!
2-FDCK 10 kg 6590 $ Toevoegen aan winkelwagen Gratis verzending!
2-FDCK is een nieuwe designer drug die is ontworpen voor onderzoek en forensische toepassingen.
Toxicologische en fysiologische eigenschappen van 2-FDCK zijn niet bestudeerd.
Opslagcondities: op een koele en droge plaats.
Bewaartijd: tot 2 jaar mits correcte opslag.
Niet bedoeld voor menselijke consumptie.
| Synoniemen | 2-Fluoroketamine, Fluoroketamine, 2-FK, 2-FDCK, 2-Fl-2′-Oxo-PCM |
|---|---|
| IUPAC | (R/S)-2-(2-fluorophenyl)-2-(methylamino)cyclohexanone |
| Formule | C13H16FNO |
| Molecuulgewicht | 221.28 g·mol−1 |
| CAS | 111982-50-4 |
| Uiterlijk | Crystalline |
| Zuiverheid | > 99 % |
| Beperking | Nee |
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2-Fluorodeschloroketamine (ook bekend als 2′-Fl-2-Oxo-PCM, fluoroketamine, en 2-FDCK) is een dissociative anesthetic gerelateerd aan ketamine. Its sale and use as a ontwerpersdrug has been reported in various countries. It is an analogue of ketamine where the chlorine group has been replaced by fluorine. Due to its recent emergence, the pharmacological specifics of the compound are mostly unclear, but effects are reported to be similar to its parent compound, ketamine.
Geschiedenis
The synthesis of 2-FDCK was first described in a 2013 paper as part of a larger effort to synthesize and evaluate new anesthetic drugs based on ketamine and its analogues. Ketamine itself was first introduced in 1964 and was approved for clinical use in 1970. Since then it has become one of the most important and applicable general anesthetics as well as a popular recreational drug.
The use of 2-FDCK as a research chemical has been reported in various countries. Many of these new psychoactive substances (NPS) appear on the drug market in order to circumvent existing drug policies. 2-FDCK was first formally notified by the EMCDDA in 2016, alongside 65 other new substances. Due to its recent appearance, little research has been done on the compound so far.
In January 2023, Israeli Biotech company “Clearmind Medicine Inc.” announced the successful completion of a preclinical study examining 2-FDCK in a rat model of depression, with the compound outperforming ketamine in longevity of antidepressant effect.
Scheikunde
Structuur
The full chemical name of 2-FDCK is 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one.
2-FDCK belongs to a class of compounds called arylcyclohexylamines which contains various other drugs such as PCP en ketamine. Their general structure consists of a cyclohexylamine unit with an aryl group attached to the same carbon as the amine. 2-FDCK has an o-fluorophenyl group as an aryl substituent and the amine group is methylated. The cyclohexyl ring features a ketone group next to the amine position.
The chemical structure of 2-FDCK differs from ketamine only in that there is a fluorine atom attached to the phenyl group. Ketamine has a chlorine atom in that position.
Synthesis
2-FDCK can be synthesized in a five-step reaction process. First 2-fluorobenzonitrile reacts with the Grignard reagent cyclopentyl magnesium bromide followed by a bromination reaction to obtain α-bromocyclopentyl-(2-fluorophenyl)-ketone. The reaction of the obtained ketone with methylamine at −40 °C then results in the formation of α-hydroxycyclopentyl-(2-fluorophenyl)-N-methylamine. Finally, the five-membered ring cyclopentanol form is expanded to a cyclohexylketone form by a thermal rearrangement reaction. HCl is used to create a water-soluble HCl salt of 2-FDCK.
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