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4-FPD or 4F-pentedrone buy , 4-fluoro-pentedrone, is a new designer drug for chemical research, is a Hexen analogue and has all its properties.
4-FPD buy and pentylone are both synthetic cathinones, a class of psychoactive substances that have emerged as novel psychoactive substances (NPS). Structurally, they are β-keto amphetamine analogues. While both are recognized for their stimulant properties, their specific interactions with monoamine transporters—the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET)—dictate their unique pharmacological profiles and psychoactive effects. Understanding these differences is crucial. 4-FPD was synthesized in a modern chemical laboratory in compliance with all standards.
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4-FPD is a drug designed for research and forensic applications. Toxicological and physiological properties of 4-FPD have not been studied. Pentylone has been characterized as a non-selective monoamine transporter inhibitor and a serotonin-releasing agent. In contrast, detailed pharmacological data for 4-FPD is less prevalent in the scientific literature. However, its structural similarity to pentedrone, a known norepinephrine-dopamine reuptake inhibitor (NDRI), allows for informed inferences about its likely mechanism of action. This guide will present the available quantitative data for pentylone and utilize data for pentedrone as a proxy for 4-FPD, with the clear acknowledgment of this substitution due to the current limitations in published research on 4-FPD.
4 fluoro pentedrone Comparative Analysis of Effects
Pentylone exhibits a profile of a relatively non-selective monoamine transporter inhibitor, with a notable potency at the norepinephrine transporter. Its classification as a serotonin-releasing
agent suggests a mechanism of action that goes beyond simple reuptake blockade, which may contribute to its reported empathogenic effects. The lower DAT/SERT ratio of pentylone compared to pentedrone indicates a more balanced action between the dopaminergic and serotonergic systems.
4-FPD, based on the data for its structural analogue pentedrone, is predicted to be a more selective norepinephrine-dopamine reuptake inhibitor (NDRI).[1] The significantly higher IC50 value for SERT suggests a much weaker interaction with the serotonin transporter compared to pentylone. This pharmacological profile would likely result in predominantly stimulant effects, with less of the serotonergic-mediated effects observed with pentylone. The addition of a fluorine atom to the phenyl ring in 4-FPD may influence its potency and selectivity, a common strategy in medicinal chemistry to modulate pharmacokinetic and pharmacodynamic properties. However, without direct experimental data, the precise impact of this substitution remains speculative.
Signaling Pathways and Experimental Workflows
To visually represent the mechanisms of action and experimental procedures discussed, the following diagrams are provided in DOT language for Graphviz.
Monoamine Transporter Inhibition
The following diagram illustrates the primary mechanism of action for both pentylone and,presumably, 4-FPD as monoamine transporter inhibitors
Storage conditions: in a cool, dry place.
Storage time: up to 2 years subject to proper storage conditions.
Not intended for human consumption.
| Synonyms | 4-FPD
4F-pentedrone 4-fluoro-pentedrone |
|---|---|
| IUPAC | 2-fluoromethyl-1-phenylpentan-1-one |
| Formula | C13H18FNO |
| Molecular weight | |
| CAS | 879669-95-1 |
| Appearance | Crystalline, Powder |
| Purity | ≥ 99 % |
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Pentedrone (also known as α-methylaminovalerophenone) is a stimulant of the cathinone class that has been sold as a designer drug and has been found since 2010 as an ingredient in a number of “bath salt” mixes sold as legal highs.
Pharmacology
Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor (NDRI) without inducing monoamine release, a similar mechanism of action to methylphenidate. Its IC50Tooltip half-maximal inhibitory concentration values for inhibition of monoamine reuptake have been reported to be 610 nM for norepinephrine, 2,500 μM for dopamine, and 135,000 μM for serotonin.In rodents, pentedrone has been found to produce conditioned place preference (CPP), to be self-administered, and to dose-dependently stimulate locomotor activity.Hence, pentedrone shows psychostimulant-like and reinforcing effects in animals.
Side effects
Pentedrone has been linked to at least one death where it was combined with α-PVP and caused heart failure.
Where to Buy 4-fluoro Pentedrone (hydrochloride) | 4-fpd buy
4-fluoro Pentedrone (hydrochloride) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic …
Application Scenarios for Pentedrone (CAS 879722-57-3) | 4-FPD buy Scenarios
Reference Standard for Selective Catecholaminergic Pathway Studies
For neuropharmacological research models where isolating the effects of dopamine and norepinephrine reuptake is critical, Pentedrone serves as an ideal tool. Its high DAT/SERT selectivity ratio ensures minimal off-target serotonergic activity, which is a known confounding variable with analogs like Methylone.
Behavioral Models Requiring Sustained, Long-Duration Stimulant Effects
In experimental paradigms such as conditioned place preference or drug discrimination that require a prolonged and stable drug effect, Pentedrone’s 67-150% longer duration of action compared to Methylone and Pentylone simplifies protocols by reducing the need for multiple administrations.
Mechanistic Control for Differentiating Reuptake Inhibition vs. Release
When investigating the neurochemical differences between cathinone classes, Pentedrone is the appropriate choice as a non-releasing reuptake inhibitor to contrast with monoamine-releasing agents like Mephedrone. This allows for direct assessment of how these distinct mechanisms contribute to cellular and behavioral outcomes.
Certified Reference Material for Forensic and Toxicological Analysis
Given its unique pharmacological profile (selectivity, duration, mechanism) and metabolic pathway, high-purity Pentedrone is essential for developing and validating analytical methods to unambiguously differentiate it from a growing list of structurally similar cathinone analogs in seized materials or biological samples.
References
- [1] Nadal-Gratacós, N., et al. (2021). Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes. Frontiers in Pharmacology, 12, 729298.
- [2] Aarde, S. M., Angrish, D., & Taffe, M. A. (2017). Locomotor and Reinforcing Effects of Pentedrone, Pentylone and Methylone in Rats. Neuropharmacology, 124, 66–75.
- [3] Gatch, M. B., Taylor, C. M., & Forster, M. J. (2015). Discriminative and locomotor effects of five synthetic cathinones in rats and mice. Psychopharmacology, 232(7), 1197–1205.
- [4] Simmler, L. D., Rickli, A., Hoener, M. C., & Liechti, M. E. (2014). Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuropharmacology, 79, 152–160.
- [5] Westphal, F., Junge, T., Girreser, U., Greibl, W., & Doering, C. (2012). Mass, NMR and IR spectroscopic characterization of pentedrone and pentylone and identification of their isocathinone by-products. Forensic science international, 217(1-3), 157–167.
