購買 5BR-ADB-INACA 粉末

購買 5BR-ADB-INACA 粉末 (N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-bromopentyl)-1H-indazole-3-acetamide) is a highly potent, novel synthetic cannabinoid belonging to the indazole-3-acetamide class.

價格：

5BR-ADBB 10 g 120 $ 加入購物車

5BR-ADBB 50 g 250 $ 加入購物車 免費運送!

5BR-ADBB 100 g 400 $ 加入購物車 免費運送!

5BR-ADBB 1 kg 1400 $ 加入購物車 免費運送!

Structurally, it is the 5-bromo analog of the widely documented 5F-ADB-INACA, featuring a bromine atom at the terminal position of the pentyl chain, combined with the ultra-effective ADB (1-amino-3,3-dimethyl-2-oxobutyl) head group and the acetamide linker. The toxicological properties of this drug are not known. The dosage of 5BR-ADB Butinaca is the same as ADB Butinaca, as shown in studies on mice.

You can 購買 5BR-ADB-INACA 粉末 online in our store right now.

In neuropharmacological research, the substitution of terminal alkyl chain hydrogens with halogens is a fundamental variable that dictates CB1/CB2 receptor affinity and metabolic stability. While fluorine (5F-) and chlorine (5Cl-) substitutions have been extensively profiled, the 5-bromo (5BR-) substitution introduces a heavy halogen into the SCRA scaffold. Bromine’s large atomic radius and high lipophilicity drastically alter the molecule’s electronic distribution and steric bulk, making 5BR-ADB-INACA a critical reference standard for mapping the structural-activity relationships (SAR) of heavy-halogenated agonists. Because SCRAs of this potency class pose severe risks of acute toxicity if accidentally exposed, extreme caution and strict in-vitro handling protocols are mandatory. Note: This product is strictly intended for in-vitro research and analytical purposes only.

Key Features and Benefits – 購買 5BR-ADB-INACA 粉末

• Heavy-Halogen SAR Mapping: 5BR-ADB-INACA provides researchers with the vital 5-bromo analog required for comparative structural-activity relationship (SAR) studies against 5-fluoro (5F-ADB-INACA) and 5-chloro (5Cl-ADB-INACA) analogs, quantifying how heavy halogen size and lipophilicity dictate CB1/CB2 binding pocket accommodation.
• Indazoleacetamide Core Profiling: Features the acetamide linker (INACA) rather than the carboxamide linker (PINACA), allowing researchers to study the combined steric effects of the methylene spacer and a terminal heavy halogen on receptor efficacy.
• Ultra-High CB1/CB2 Agonist Modeling: As an ADB-core full agonist, it allows the study of maximal receptor activation and subsequent downregulation/internalization at extreme ligand concentrations.
• Forensic Early-Adopter Standard: Essential for forensic and analytical laboratories requiring a pure, verified reference material to proactively calibrate LC/MS and GC/MS instruments, enabling the detection of brominated indazoleacetamides in complex biological matrices.
• Metabolic Profiling: Ideal for analyzing the hepatic breakdown, oxidative debromination, and alkyl chain degradation of heavy-halogenated SCRAs using hepatocyte cultures and liver microsomes.

Applications and Usage

5BR-ADB-INACA Powder is exclusively designated for in-vitro (outside a living organism) research and analytical applications. Common laboratory applications include:

• Cannabinoid Receptor Binding Assays: Investigating the compound’s ultra-high affinity and full agonist efficacy at CB1 and CB2 receptors, and contrasting its binding kinetics with 5-fluoro and 5-chloro analogs.
• Heavy-Halogen SAR Studies: Mapping the steric and electronic consequences of the large atomic radius of bromine on the terminal pentyl chain, and determining the limits of the CB1 binding pocket’s accommodation for heavy atoms.
• Metabolic Profiling: Analyzing the hepatic breakdown, debromination, and metabolite identification of 5-bromo substituted cannabinoids using hepatocyte cultures and liver microsomes.
• Forensic and Analytical Calibration: Utilizing 5BR-ADB-INACA as a certified reference material (CRM) for GC/MS, LC/MS, and NMR spectroscopy to validate analytical instruments and identify emerging brominated NPS in biological matrices.

Disclaimer: This product is not for human or veterinary consumption. It must only be handled in controlled laboratory environments by qualified professionals.

Purity and Testing

We guarantee a purity level of ≥ 98% for our 5BR-ADB-INACA Powder. Every batch undergoes rigorous, independent third-party testing to verify chemical identity, absolute purity, and the absence of dangerous residual solvents, heavy metals, or unreacted precursors. Because indazoleacetamides and brominated compounds are prone to degradation, special analytical care is taken to ensure minimal presence of degradation products. Certificates of Analysis (CoA) and Safety Data Sheets (SDS) are provided upon request.

Toxicological and physiological properties of 5BR-ADBB have not been studied.

5BR-ADBB synthesized in the modern laboratory in compliance with all standards.

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Frequently Asked Questions (FAQ)

Q1: What is 5BR-ADB-INACA?
A: 5BR-ADB-INACA (N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-bromopentyl)-1H-indazole-3-acetamide) is a novel synthetic cannabinoid from the indazole-3-acetamide class. It features a bromine atom on the terminal pentyl chain and acts as an ultra-potent full agonist at both CB1 and CB2 receptors.

Q2: What makes 5BR-ADB-INACA different from 5F-ADB-INACA?
A: The primary difference is the terminal halogen on the pentyl chain. 5F-ADB-INACA features a fluorine atom (a small, highly electronegative, and stable halogen), while 5BR-ADB-INACA features a bromine atom (a heavy halogen with a large atomic radius and high lipophilicity). This drastic difference in size and polarity alters how the molecule fits into the CB1 binding pocket, making it essential for comparative heavy-halogen SAR research.

Q3: What is the significance of the “INACA” in the name?
A: “INACA” stands for indazole-3-乙醯胺, meaning there is an extra methylene (CH2) group between the indazole ring and the carbonyl group, compared to the “PINACA” (indazole-3-carboxamide) structure. This alters the spatial orientation of the ADB head group relative to the core, providing a distinct SAR variable for receptor binding studies.

Q4: Can 5BR-ADB-INACA be consumed?
A: Absolutely NOT. 5BR-ADB-INACA is an ultra-potent full agonist at CB1 receptors, far exceeding the potency of natural THC. Ingestion can cause severe, life-threatening psychological and physiological effects, including severe seizures and death, and is strictly prohibited.

Q5: Do you provide a Certificate of Analysis (CoA)?
A: Yes. We provide a comprehensive CoA—including HPLC, GC/MS, and NMR data—for every batch we sell. This guarantees the identity, purity, and mass of the compound.

Q6: Is it legal to buy 5BR-ADB-INACA in my country?
A: Legality varies drastically by country and is subject to change. Because it is a synthetic cannabinoid, it is often controlled under analogue acts or specific NPS bans. We cannot provide legal advice. It is your responsibility to research your local laws regarding this compound before placing an order.

Q7: How should I store 5BR-ADB-INACA for long-term research?
A: For maximum longevity, store 5BR-ADB-INACA in an airtight, amber glass vial under an inert gas (like Argon) in a freezer set to -20°C. Keep away from direct sunlight, heat, and moisture.