{"id":7912,"date":"2026-07-04T15:44:44","date_gmt":"2026-07-04T15:44:44","guid":{"rendered":"https:\/\/chemsaxis.com\/?p=7912"},"modified":"2026-07-23T04:24:03","modified_gmt":"2026-07-23T04:24:03","slug":"3-meo-pce-3-methoxyeticyclidine-2","status":"publish","type":"post","link":"https:\/\/chemsaxis.com\/zh\/3-meo-pce-3-methoxyeticyclidine-2\/","title":{"rendered":"3-MeO-PCE (3-\u7532\u6c27\u57fa\u4e59\u74b0\u5229\u5b9a)"},"content":{"rendered":"<figure id=\"attachment_909\" class=\"wp-caption alignleft\" aria-describedby=\"caption-attachment-909\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"\/shop\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-909 size-medium\" src=\"https:\/\/chembeyond.com\/wp-content\/uploads\/2019\/12\/3-MeO-PCE-300x225.jpg\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" srcset=\"https:\/\/chembeyond.com\/wp-content\/uploads\/2019\/12\/3-MeO-PCE-300x225.jpg 300w, https:\/\/chembeyond.com\/wp-content\/uploads\/2019\/12\/3-MeO-PCE.jpg 560w\" alt=\"buy\u00a03-MeO-PCE\u00a0online\" width=\"300\" height=\"225\" \/><\/a><\/span><figcaption id=\"caption-attachment-909\" class=\"wp-caption-text\"><span style=\"color: #000000;\">3-MeO-PCE<\/span><\/figcaption><\/figure>\n<h1><span class=\"tlid-translation translation\" lang=\"en\" style=\"color: #000000;\"><span class=\"\" title=\"\"> buy\u00a0<span title=\"\">3-MeO-PCE\u00a0<\/span>online | Wholesale <span title=\"\">3-MeO-PCE<\/span><\/span><\/span><\/h1>\n<p><span class=\"tlid-translation translation\" lang=\"en\" style=\"color: #000000;\"><span title=\"\">Buy 3-MeO-PCE online, (3-Methoxyeticyclidine) is a new designer substance of the dissociative class arylcyclohexylamine, which causes hallucinations.<\/span>\u00a0<span class=\"\" title=\"\">3-MeO-PCE is a structural analogue of PCE and 3-MeO-PCP and has a similar effect on rodent organisms in studies.<\/span><\/span><\/p>\n<p><span style=\"color: #000000;\">Price:<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong><span class=\"tlid-translation translation\" lang=\"en\"><span title=\"\">3-MeO-PCE<\/span><\/span>\u00a010g 179 $\u00a0<span style=\"color: #ff0000;\"><a class=\"fancybox-inline\" style=\"color: #ff0000;\" href=\"https:\/\/chemsaxis.com\/order-inquiry-page\/\"><b>Add to cart<\/b><\/a><\/span><br \/>\n<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong><span class=\"tlid-translation translation\" lang=\"en\"><span title=\"\">3-MeO-PCE<\/span><\/span>\u00a0100g 990 $\u00a0<span style=\"color: #ff0000;\"><a class=\"fancybox-inline\" style=\"color: #ff0000;\" href=\"https:\/\/chemsaxis.com\/order-inquiry-page\/\"><b>Add to cart <\/b><\/a><\/span><\/strong><strong><span id=\"result_box\" class=\"short_text\" lang=\"en\"><span class=\"\">Free shipping<\/span><\/span>!<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong><span class=\"tlid-translation translation\" lang=\"en\"><span title=\"\">3-MeO-PCE<\/span><\/span>\u00a0500g 2690 $\u00a0<span style=\"color: #ff0000;\"><a class=\"fancybox-inline\" style=\"color: #ff0000;\" href=\"https:\/\/chemsaxis.com\/order-inquiry-page\/\"><b>Add to cart <\/b><\/a><\/span><\/strong><strong><span id=\"result_box\" class=\"short_text\" lang=\"en\"><span class=\"\">Free shipping<\/span><\/span>!<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong><span class=\"tlid-translation translation\" lang=\"en\"><span title=\"\">3-MeO-PCE<\/span><\/span>\u00a01 kg 3590 $\u00a0<a class=\"fancybox-inline\" style=\"color: #000000;\" href=\"https:\/\/chemsaxis.com\/order-inquiry-page\/\"><b><span style=\"color: #ff0000;\">Add to cart<\/span> <\/b><\/a><\/strong><strong><span id=\"result_box\" class=\"short_text\" lang=\"en\"><span class=\"\">Free shipping<\/span><\/span>!<\/strong><\/span><\/p>\n<h3><span class=\"tlid-translation translation\" lang=\"en\" style=\"color: #000000;\"><span class=\"\" title=\"\">You can buy\u00a0<span title=\"\">3-MeO-PCE\u00a0<\/span>online right now at Chemsaxis.<\/span><\/span><\/h3>\n<p><span style=\"color: #000000;\"><span class=\"tlid-translation translation\" lang=\"en\"><span title=\"\">Buy 3-MeO-PCE online from chems axis which <\/span><\/span>is a designer drug intended for research and forensic analysis.\u00a0<span class=\"tlid-translation translation\" lang=\"en\"><span title=\"\">3-MeO-PCE\u00a0<\/span><\/span>is produced in modern pharmaceutical laboratory in compliance with all quality standards.<\/span><\/p>\n<p><span style=\"color: #000000;\">Storage conditions: in a cool and dry place,<\/span><br \/>\n<span style=\"color: #000000;\">storage for up to 2 years.<\/span><\/p>\n<figure id=\"attachment_910\" class=\"wp-caption alignleft\" aria-describedby=\"caption-attachment-910\"><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/chembeyond.com\/wp-content\/uploads\/2019\/12\/3-MeO-PCE.png\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-910\" src=\"https:\/\/chembeyond.com\/wp-content\/uploads\/2019\/12\/3-MeO-PCE-300x227.png\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" srcset=\"https:\/\/chembeyond.com\/wp-content\/uploads\/2019\/12\/3-MeO-PCE-300x227.png 300w, https:\/\/chembeyond.com\/wp-content\/uploads\/2019\/12\/3-MeO-PCE.png 329w\" alt=\"3-MeO-PCE\" width=\"300\" height=\"227\" \/><\/a><\/span><figcaption id=\"caption-attachment-910\" class=\"wp-caption-text\"><span style=\"color: #000000;\">3-MeO-PCE<\/span><\/figcaption><\/figure>\n<table class=\"wp-block-table\">\n<tbody>\n<tr>\n<th><span style=\"color: #000000;\">Synonyms<\/span><\/th>\n<td><span style=\"color: #000000;\">3-MeO-PCE<\/span><br \/>\n<span style=\"color: #000000;\">3-methoxy Eticyclidine<\/span><\/td>\n<\/tr>\n<tr>\n<th><span style=\"color: #000000;\">IUPAC<\/span><\/th>\n<td><span style=\"color: #000000;\">N-ethyl-1-(3-methoxyphenyl)-cyclohexanamine, monohydrochloride<\/span><\/td>\n<\/tr>\n<tr>\n<th><span style=\"color: #000000;\">Formula<\/span><\/th>\n<td><span style=\"color: #000000;\">C<sub>15<\/sub>H<sub>23<\/sub>NO \u2022 HCl<\/span><\/td>\n<\/tr>\n<tr>\n<th><span style=\"color: #000000;\">Molecular weight<\/span><\/th>\n<td><span style=\"color: #000000;\">269.8<\/span><\/td>\n<\/tr>\n<tr>\n<th><span style=\"color: #000000;\">CAS<\/span><\/th>\n<td><span style=\"color: #000000;\">1797121-52-8<\/span><\/td>\n<\/tr>\n<tr>\n<th><span style=\"color: #000000;\">Appearance<\/span><\/th>\n<td><span style=\"color: #000000;\">powder<\/span><\/td>\n<\/tr>\n<tr>\n<th><span style=\"color: #000000;\">Purity<\/span><\/th>\n<td><span style=\"color: #000000;\">&gt; 99 %<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><span id=\"result_box\" class=\"\" lang=\"en\" style=\"color: #000000;\"><span class=\"\">-Choose your favorite products from Chemsaxis, and you are guaranteed excellent quality at the best price.<\/span><\/span><\/p>\n<p><span class=\"\" style=\"color: #000000;\">-Envelopes are sent 24 hours after payment.<\/span><br \/>\n<span style=\"color: #000000;\">Delivery time 3-4 business days.<\/span><br \/>\n<span style=\"color: #000000;\">100% delivery speed throughout Europe.<\/span><\/p>\n<p><span class=\"\" style=\"color: #000000;\">-You must know the legal status of the product you order in your country.<\/span><br \/>\n<span style=\"color: #000000;\"><span class=\"\">-When ordering on our website from 250 US dollars, delivery at our expense.<\/span>\u00a0<span class=\"\">The manager automatically excludes shipping costs when ordering from $ 250.<\/span><\/span><\/p>\n<div class=\"card\">\n<div id=\"collapseSource\" class=\"collapse show\" aria-labelledby=\"Source\">\n<div class=\"card-body\">\n<p><span style=\"color: #000000;\">Buy 3-Methoxy pceonline from chems axis, with reference materials available for research purposes. For example, Chems Axis provides analytical standards for this compound, ensuring quality and purity for scientific applications<a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/www.cfsre.org\/images\/monographs\/MeO-PCE_121020_CFSRE_Toxicology_Report.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"[PDF] MeO-PCE - CFSRE&#039;s\" data-state=\"closed\">\u00a0<\/a><span class=\"whitespace-nowrap\"><a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/www.lgcstandards.com\/SH\/en\/3-MeO-PCE-HCl-3-Methoxyeticyclidine-Hydrochloride-2-3-Methoxyphenyl-2-ethylamino-cyclohexane-Hydrochloride-\/p\/LGCFOR1366.10?queryID=8c326dcdc3528d379742eb2206319221\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"3-MeO-PCE HCl (3-Methoxyeticyclidine Hydrochloride\" data-state=\"closed\">\u00a0<\/a>.<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div id=\"Classification\" class=\"card-header\"><span class=\"accordion-title\" style=\"color: #000000;\">Classification<\/span><\/div>\n<div id=\"collapseClassification\" class=\"collapse show\" aria-labelledby=\"Classification\">\n<div class=\"card-body\">\n<ul>\n<li><span style=\"color: #000000;\"><strong>Chemical Class<\/strong>: Dissociative anesthetic<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>IUPAC Name<\/strong>: N-ethyl-1-(3-methoxyphenyl)cyclohexanamine hydrochloride<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>CAS Number<\/strong>: 1797121-52-8<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Molecular Formula<\/strong>: C15H23NO\u00b7ClH<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div id=\"Synthesis Analysis\" class=\"card-header\"><span class=\"accordion-title\" style=\"color: #000000;\">Synthesis Analysis<\/span><\/div>\n<div id=\"collapseSynthesis Analysis\" class=\"collapse show\" aria-labelledby=\"Synthesis Analysis\">\n<div class=\"card-body\">\n<h3><span style=\"color: #000000;\">Methods<\/span><\/h3>\n<p><span style=\"color: #000000;\">The synthesis of 3-methoxy pce typically involves the reaction of 3-methoxyphenylacetonitrile with ethylamine in the presence of a reducing agent. The process can be adapted for use in forensic laboratories and by chemists involved in the gray market.<\/span><\/p>\n<h3><span style=\"color: #000000;\">Technical Details<\/span><\/h3>\n<p><span style=\"color: #000000;\">The original synthesis described by Geneste et al. has been optimized to allow the production of 3-methoxy pce within a few days using standard laboratory reagents and high-performance liquid chromatography grade solvents. The modified methods include various purification steps to ensure high yields and purity levels suitable for research applications<a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/cdn.who.int\/media\/docs\/default-source\/controlled-substances\/43rd-ecdd\/3-meo-pcp-finalreport-a.pdf?sfvrsn=8c513cd7_2\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"[PDF] Critical Review Report: 3-Methoxyphencyclidine 3-MeO-PCP\" data-state=\"closed\">\u00a0<\/a><span class=\"whitespace-nowrap\"><a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/en.wikipedia.org\/wiki\/3-MeO-PCE\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"3-MeO-PCE - Wikipedia\" data-state=\"closed\">\u00a0<\/a>.<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div id=\"Molecular Structure Analysis\" class=\"card-header\"><span class=\"accordion-title\" style=\"color: #000000;\">Molecular Structure Analysis<\/span><\/div>\n<div id=\"collapseMolecular Structure Analysis\" class=\"collapse show\" aria-labelledby=\"Molecular Structure Analysis\">\n<div class=\"card-body\">\n<h3><span style=\"color: #000000;\">Structure<\/span><\/h3>\n<p><span style=\"color: #000000;\">The molecular structure of 3-methoxy pce features a cyclohexane ring substituted with an ethylamine group and a methoxyphenyl group. This configuration is crucial for its pharmacological activity.<\/span><\/p>\n<h3><span style=\"color: #000000;\">Data<\/span><\/h3>\n<ul>\n<li><span style=\"color: #000000;\"><strong>Molecular Weight<\/strong>: 269.81 g\/mol<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Melting Point<\/strong>: Approximately 204 \u00b0C<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Boiling Point<\/strong>: Approximately 381 \u00b0C<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\">The structural formula can be expressed as follows:<\/span><\/p>\n<div class=\"math math-display\"><span class=\"katex-display\" style=\"color: #000000;\"><span class=\"katex\"><span class=\"katex-mathml\">C15H23NO\u22c5ClH<\/span><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord text\">C<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">15<\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><span class=\"mord\"><span class=\"mord text\">H<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">23<\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><span class=\"mord text\"><span class=\"mord\">N<\/span><\/span><span class=\"mord text\"><span class=\"mord\">O<\/span><\/span><span class=\"mbin\">\u22c5<\/span><\/span><span class=\"base\"><span class=\"mord text\"><span class=\"mord\">ClH<\/span><\/span><\/span><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div id=\"Chemical Reactions Analysis\" class=\"card-header\"><span class=\"accordion-title\" style=\"color: #000000;\">Chemical Reactions Analysis<\/span><\/div>\n<div id=\"collapseChemical Reactions Analysis\" class=\"collapse show\" aria-labelledby=\"Chemical Reactions Analysis\">\n<div class=\"card-body\">\n<h3><span style=\"color: #000000;\">Reactions<\/span><\/h3>\n<p><span style=\"color: #000000;\">3-Methoxy pce undergoes various chemical reactions typical of amines and ethers, including oxidation and hydrolysis. The compound&#8217;s reactivity can be attributed to the presence of the methoxy group, which can participate in electrophilic aromatic substitution reactions.<\/span><\/p>\n<h3><span style=\"color: #000000;\">Technical Details<\/span><\/h3>\n<p><span style=\"color: #000000;\">Analytical methods such as liquid chromatography coupled with mass spectrometry have been employed to study the metabolites produced from the metabolism of 3-methoxy pce. These studies have identified several phase I and phase II metabolites resulting from hydroxylation, O-demethylation, and glucuronidation processes<a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/cdn.who.int\/media\/docs\/default-source\/controlled-substances\/43rd-ecdd\/3-meo-pcp-finalreport-a.pdf?sfvrsn=8c513cd7_2\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"[PDF] Critical Review Report: 3-Methoxyphencyclidine 3-MeO-PCP\" data-state=\"closed\">\u00a0<\/a><span class=\"whitespace-nowrap\"><a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/www.cfsre.org\/images\/monographs\/MeO-PCE_121020_CFSRE_Toxicology_Report.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"[PDF] MeO-PCE - CFSRE&#039;s\" data-state=\"closed\">\u00a0<\/a>.<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div id=\"Mechanism of Action\" class=\"card-header\"><span class=\"accordion-title\" style=\"color: #000000;\">Mechanism of Action<\/span><\/div>\n<div id=\"collapseMechanism of Action\" class=\"collapse show\" aria-labelledby=\"Mechanism of Action\">\n<div class=\"card-body\">\n<h3><span style=\"color: #000000;\">Process<\/span><\/h3>\n<p><span style=\"color: #000000;\">The mechanism of action of 3-methoxy pce primarily involves antagonism at the N-methyl-D-aspartate receptor in the central nervous system. This action leads to dissociative effects similar to those observed with other compounds like phencyclidine and ketamine.<\/span><\/p>\n<h3><span style=\"color: #000000;\">Data<\/span><\/h3>\n<p><span style=\"color: #000000;\">Pharmacological studies indicate that 3-methoxy pce exhibits significant binding affinity at NMDA receptors, with a reported\u00a0<span class=\"math math-inline\"><span class=\"katex\"><span class=\"katex-mathml\">Ki<\/span><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">K<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mathnormal mtight\">i<\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>\u00a0value indicating its potency in inhibiting receptor activity<span class=\"whitespace-nowrap\"><a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3602154\/\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"The Ketamine Analogue Methoxetamine and 3\" data-state=\"closed\">\u00a0<\/a>.<\/span>\u00a0Additionally, it interacts with serotonin transporters, contributing to its psychoactive effects.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div id=\"Physical and Chemical Properties Analysis\" class=\"card-header\"><span class=\"accordion-title\" style=\"color: #000000;\">Physical and Chemical Properties Analysis<\/span><\/div>\n<div id=\"collapsePhysical and Chemical Properties Analysis\" class=\"collapse show\" aria-labelledby=\"Physical and Chemical Properties Analysis\">\n<div class=\"card-body\">\n<h3><span style=\"color: #000000;\">Physical Properties<\/span><\/h3>\n<h3><span style=\"color: #000000;\">Chemical Properties<\/span><\/h3>\n<ul>\n<li><span style=\"color: #000000;\"><strong>Stability<\/strong>: Generally stable under standard laboratory conditions.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Reactivity<\/strong>: Reacts with strong oxidizing agents; care should be taken during handling.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\">Relevant analyses have shown that 3-methoxy pce maintains its integrity under various conditions typical for laboratory environments<a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/www.cfsre.org\/images\/monographs\/MeO-PCE_121020_CFSRE_Toxicology_Report.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"[PDF] MeO-PCE - CFSRE&#039;s\" data-state=\"closed\">\u00a0<\/a><span class=\"whitespace-nowrap\"><a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/www.lgcstandards.com\/SH\/en\/3-MeO-PCE-HCl-3-Methoxyeticyclidine-Hydrochloride-2-3-Methoxyphenyl-2-ethylamino-cyclohexane-Hydrochloride-\/p\/LGCFOR1366.10?queryID=8c326dcdc3528d379742eb2206319221\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"3-MeO-PCE HCl (3-Methoxyeticyclidine Hydrochloride\" data-state=\"closed\">\u00a0<\/a>.<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div id=\"Applications\" class=\"card-header\"><span class=\"accordion-title\" style=\"color: #000000;\">Applications<\/span><\/div>\n<div id=\"collapseApplications\" class=\"collapse show\" aria-labelledby=\"Applications\">\n<div class=\"card-body\">\n<h3><span style=\"color: #000000;\">Scientific Uses<\/span><\/h3>\n<p><span style=\"color: #000000;\">3-Methoxy pce is primarily used in research settings to explore its pharmacological properties and potential therapeutic applications. Its role as a dissociative anesthetic makes it a candidate for studies related to pain management and mental health disorders.<\/span><\/p>\n<p><span style=\"color: #000000;\">Additionally, its structural similarity to other psychoactive compounds makes it valuable for understanding the mechanisms underlying dissociation and anesthetic effects in clinical settings<span class=\"whitespace-nowrap\"><a class=\"citation ml-xs inline\" style=\"color: #000000;\" href=\"https:\/\/en.wikipedia.org\/wiki\/3-MeO-PCE\" target=\"_blank\" rel=\"nofollow noopener\" aria-label=\"3-MeO-PCE - Wikipedia\" data-state=\"closed\">\u00a0<\/a>.<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div id=\"chemical_characterization_of_3-methoxy-pce_(hydrochloride)\" class=\"card-header\"><span class=\"accordion-title\" style=\"color: #000000;\">Chemical Characterization of 3-Methoxy-PCE (Hydrochloride)<\/span><\/div>\n<div id=\"collapsechemical_characterization_of_3-methoxy-pce_(hydrochloride)\" class=\"collapse show\" aria-labelledby=\"chemical_characterization_of_3-methoxy-pce_(hydrochloride)\">\n<div class=\"card-body\">\n<h3><span style=\"color: #000000;\">Structural Elucidation and Isomeric Differentiation<\/span><\/h3>\n<h4><span style=\"color: #000000;\">Comparative Analysis with Arylcyclohexylamine Derivatives<\/span><\/h4>\n<p><span style=\"color: #000000;\">3-Methoxy-PCE hydrochloride (C\u2081\u2085H\u2082\u2084ClNO; CAS 1797121-52-8) belongs to the\u00a0<em>arylcyclohexylamine<\/em>\u00a0class, sharing core structural motifs with established dissociative anesthetics while exhibiting distinct substitutions that define its pharmacological profile. Its molecular architecture comprises a cyclohexyl ring bridged to a nitrogen-containing ethylamino group (\u2011NCH\u2082CH\u2083) and a 3-methoxyphenyl aromatic system\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.medchemexpress.com\/3-methoxy-pce-hydrochloride.html?srsltid=AfmBOopW1EGbaimVILcmebkvdJzjn7iz3um9U-ewdn0ZIdf1fqvMbRM7\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>. This configuration differs critically from several key analogues:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\"><strong>Phencyclidine (PCP)<\/strong>: Features a piperidine ring instead of the ethylamino group. The piperidine nitrogen is incorporated into a heterocyclic structure (\u2011N&lt; within a six-membered ring), increasing steric bulk and altering receptor engagement kinetics compared to 3-MeO-PCE&#8217;s flexible ethyl chain\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Ketamine<\/strong>: Possesses an ortho-chlorinated phenyl ring and a \u03b2-keto group adjacent (alpha) to the cyclohexylamine nitrogen. The \u03b2-keto moiety significantly influences hydrogen bonding potential and metabolic pathways, absent in 3-MeO-PCE\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a>\u00a0.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>3-MeO-PCP<\/strong>: Shares the meta-methoxy phenyl substitution but incorporates a piperidine ring analogous to PCP, contrasting with 3-MeO-PCE\u2019s N-ethyl group. This difference impacts lipophilicity and NMDA receptor binding kinetics\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a>.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\">The\u00a0<em>N-ethyl<\/em>\u00a0moiety in 3-MeO-PCE reduces steric hindrance near the nitrogen atom compared to the constrained piperidine in PCP\/3-MeO-PCP, potentially enhancing conformational flexibility and receptor interaction dynamics. Simultaneously, the\u00a0<em>meta-methoxy<\/em>\u00a0(\u2011OCH\u2083) group on the phenyl ring is a strong electron-donating substituent, influencing the aromatic ring&#8217;s electron density and its interaction with hydrophobic receptor pockets. This substitution pattern is a key determinant of its receptor affinity profile among arylcyclohexylamines\u00a0<a style=\"color: #000000;\" href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/121230793\" target=\"_blank\" rel=\"noopener\">[1]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a>.<\/span><\/p>\n<p><span style=\"color: #000000;\"><em>Table 1: Structural Comparison of Key Arylcyclohexylamines<\/em><\/span><\/p>\n<table>\n<thead>\n<tr>\n<th><span style=\"color: #000000;\"><strong>Compound<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>Aromatic Ring Substitution<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>Amino Group<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>Cyclohexyl Modification<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>Molecular Formula (Base\/HCl)<\/strong><\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"color: #000000;\"><strong>3-MeO-PCE (HCl)<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">3-methoxy (meta-OCH\u2083)<\/span><\/td>\n<td><span style=\"color: #000000;\">-N(H)CH\u2082CH\u2083<\/span><\/td>\n<td><span style=\"color: #000000;\">None<\/span><\/td>\n<td><span style=\"color: #000000;\">C\u2081\u2085H\u2082\u2083NO \/ C\u2081\u2085H\u2082\u2084ClNO<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>PCP<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">None<\/span><\/td>\n<td><span style=\"color: #000000;\">Piperidine (\u2011N&lt; ring)<\/span><\/td>\n<td><span style=\"color: #000000;\">None<\/span><\/td>\n<td><span style=\"color: #000000;\">C\u2081\u2087H\u2082\u2085N<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Ketamine<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">2-chloro (ortho-Cl)<\/span><\/td>\n<td><span style=\"color: #000000;\">-N(CH\u2083)CH\u2083 (Dimethyl)<\/span><\/td>\n<td><span style=\"color: #000000;\">\u03b2-Keto group<\/span><\/td>\n<td><span style=\"color: #000000;\">C\u2081\u2083H\u2081\u2086ClNO<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>3-MeO-PCP<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">3-methoxy (meta-OCH\u2083)<\/span><\/td>\n<td><span style=\"color: #000000;\">Piperidine (\u2011N&lt; ring)<\/span><\/td>\n<td><span style=\"color: #000000;\">None<\/span><\/td>\n<td><span style=\"color: #000000;\">C\u2081\u2088H\u2082\u2087NO<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4><span style=\"color: #000000;\">Positional Isomer Discrimination: 3-MeO-PCE vs. 4-MeO-PCE<\/span><\/h4>\n<p><span style=\"color: #000000;\">Positional isomerism within methoxy-substituted arylcyclohexylamines significantly influences pharmacological activity. The\u00a0<em>meta<\/em>\u00a0(3-) versus\u00a0<em>para<\/em>\u00a0(4-) positioning of the methoxy group on the phenyl ring alters electronic distribution, molecular dipole, and steric presentation during receptor binding.<\/span><\/p>\n<p><span style=\"color: #000000;\">3-MeO-PCE exhibits the oxygen atom of its methoxy group projecting towards the amino-cyclohexyl moiety. This positioning creates a distinct electronic profile where the electron-donating resonance effect of the methoxy group is partially suppressed compared to the\u00a0<em>para<\/em>\u00a0isomer. In contrast, the 4-MeO-PCE isomer (methoxy group opposite the attachment point to the cyclohexyl ring) allows for maximal resonance donation into the phenyl ring system. This difference profoundly impacts NMDA receptor affinity:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\"><strong>Receptor Affinity<\/strong>: 3-MeO-PCE demonstrates a significantly higher affinity for the NMDA receptor (PCP binding site; pK\u1d62 ~7.22, K\u1d62 ~61 nM) compared to 4-MeO-PCE\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOopv4m47sXEAaiWKncvGxNTIBa0epx0YeR32V3nODLqmIcsXH72a\" target=\"_blank\" rel=\"noopener\">[6]<\/a>. This enhanced affinity is attributed to optimal steric and electronic complementarity within the receptor&#8217;s binding pocket afforded by the\u00a0<em>meta<\/em>\u00a0substitution.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Analytical Discrimination<\/strong>: Techniques like UPLC-HRMS and GC-MS readily differentiate these isomers based on retention times and characteristic fragment ions. Key fragmentation pathways involve cleavage of the bond between the cyclohexyl ring and the amino nitrogen, and loss of the methoxy group or ethylene from the N-ethyl chain, yielding patterns whose relative intensities differ subtly between isomers\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a>.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\">The\u00a0<em>meta<\/em>\u00a0position in 3-MeO-PCE is thus pharmacologically privileged over the\u00a0<em>para<\/em>\u00a0position for NMDA receptor antagonism within the PCE structural framework.<\/span><\/p>\n<p><span style=\"color: #000000;\"><em>Table 2: Positional Isomer Comparison: 3-MeO-PCE vs. 4-MeO-PCE<\/em><\/span><\/p>\n<table>\n<thead>\n<tr>\n<th><span style=\"color: #000000;\"><strong>Property<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>3-MeO-PCE<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>4-MeO-PCE<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>Significance<\/strong><\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Methoxy Position<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">Meta (position 3)<\/span><\/td>\n<td><span style=\"color: #000000;\">Para (position 4)<\/span><\/td>\n<td><span style=\"color: #000000;\">Alters electron density distribution &amp; dipole moment.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>NMDA Receptor Affinity (K\u1d62)<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">~61 nM\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOopv4m47sXEAaiWKncvGxNTIBa0epx0YeR32V3nODLqmIcsXH72a\" target=\"_blank\" rel=\"noopener\">[6]<\/a><\/span><\/td>\n<td><span style=\"color: #000000;\">Lower than 3-MeO-PCE<\/span><\/td>\n<td><span style=\"color: #000000;\"><strong>3-MeO-PCE is a more potent NMDA antagonist.<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>\u03c31 Receptor Affinity (K\u1d62)<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">~4519 nM\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a><\/span><\/td>\n<td><span style=\"color: #000000;\">Not Well Characterized<\/span><\/td>\n<td><span style=\"color: #000000;\">Negligible affinity for 3-MeO-PCE.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>SERT Affinity (K\u1d62)<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">~115 nM\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOootIY4tbt87YiqV_6Bryw4g58V_EC-BZ6O38obTPbvBq_brsFpz\" target=\"_blank\" rel=\"noopener\">[5]<\/a><\/span><\/td>\n<td><span style=\"color: #000000;\">Not Well Characterized<\/span><\/td>\n<td><span style=\"color: #000000;\">Moderate affinity suggests potential secondary activity.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><span style=\"color: #000000;\">Physicochemical Properties<\/span><\/h3>\n<h4><span style=\"color: #000000;\">Hydrochloride Salt Stability and Bioavailability<\/span><\/h4>\n<p><span style=\"color: #000000;\">The hydrochloride (HCl) salt form of 3-MeO-PCE is the predominant and most stable formulation encountered. The ionic bond formed between the basic secondary amine nitrogen (\u2011NH\u2011) of the 3-MeO-PCE freebase and hydrochloric acid creates a crystalline, typically white to off-white solid\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.medchemexpress.com\/3-methoxy-pce-hydrochloride.html?srsltid=AfmBOopW1EGbaimVILcmebkvdJzjn7iz3um9U-ewdn0ZIdf1fqvMbRM7\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>. This salt formation confers critical advantages:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\"><strong>Enhanced Stability<\/strong>: The ionic crystalline lattice significantly reduces volatility and susceptibility to oxidative degradation compared to the freebase oil. This improves shelf life and facilitates handling and storage. The recommended storage condition is at room temperature or below, protected from excessive moisture and light\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.medchemexpress.com\/3-methoxy-pce-hydrochloride.html?srsltid=AfmBOopW1EGbaimVILcmebkvdJzjn7iz3um9U-ewdn0ZIdf1fqvMbRM7\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Improved Water Solubility<\/strong>: While inherently lipophilic, salt formation dramatically increases water solubility relative to the freebase. This ionization is crucial for dissolution in biological aqueous environments (e.g., gastrointestinal fluid, blood plasma), a prerequisite for systemic bioavailability after oral or insufflated administration\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.medchemexpress.com\/3-methoxy-pce-hydrochloride.html?srsltid=AfmBOopW1EGbaimVILcmebkvdJzjn7iz3um9U-ewdn0ZIdf1fqvMbRM7\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>. The protonated amine (\u2011NH\u2082\u207a\u2011) facilitates hydration and interaction with polar solvent molecules.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Bioavailability Implications<\/strong>: The hydrochloride salt ensures rapid dissolution and absorption across mucous membranes. Once absorbed, the compound&#8217;s ability to cross the blood-brain barrier (BBB) is governed by its partition coefficient and plasma protein binding. The moderate lipophilicity of the molecule, even in its protonated form, allows sufficient passive diffusion through lipid membranes for CNS activity. The salt form itself dissociates readily in physiological pH, releasing the freebase or mono-protonated species that can permeate the BBB\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.medchemexpress.com\/3-methoxy-pce-hydrochloride.html?srsltid=AfmBOopW1EGbaimVILcmebkvdJzjn7iz3um9U-ewdn0ZIdf1fqvMbRM7\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>.<\/span><\/li>\n<\/ul>\n<h4><span style=\"color: #000000;\">Solubility and Partition Coefficients<\/span><\/h4>\n<p><span style=\"color: #000000;\">The physicochemical behavior of 3-MeO-PCE hydrochloride in different solvents is defined by its polar ionic group and the large hydrophobic domains (cyclohexyl and methoxyphenyl rings).<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\"><strong>Solubility<\/strong>:<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Water<\/strong>: Moderately soluble due to the ionic nature of the hydrochloride salt. Exact quantitative solubility data in pure water is limited in the literature, but it is sufficient for dissolution in biological fluids.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Methanol\/ Ethanol<\/strong>: Highly soluble. Solutions at 1.0 mg\/mL (as freebase equivalent) in methanol are commercially available as analytical standards, indicating good solubility\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Organic Solvents (e.g., Chloroform, Ethyl Acetate)<\/strong>: The freebase form is soluble, but the hydrochloride salt has significantly lower solubility in non-polar or weakly polar organic solvents due to its ionic character\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Partition Coefficient (Log P)<\/strong>: The Log P (octanol-water partition coefficient) is a critical parameter predicting membrane permeability and distribution. While experimental Log P values for 3-MeO-PCE HCl are scarce, calculated values (cLog P) for the freebase form are estimated around ~3.5-4.0, indicating significant lipophilicity. The hydrochloride salt exhibits a lower\u00a0<em>apparent<\/em>\u00a0Log D (distribution coefficient at physiological pH ~7.4) due to ionization. A substantial fraction of the molecule exists in the charged, hydrophilic form at pH 7.4, reducing its effective lipophilicity compared to the freebase. Nevertheless, sufficient unionized molecules exist (governed by its pKa) to allow passive diffusion through lipid bilayers, explaining its CNS penetration. The meta-methoxy group contributes favorably to lipophilicity compared to unsubstituted PCE\u00a0[4]\u00a0[5].<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><em>Table 3: Key Physicochemical Properties of 3-MeO-PCE Hydrochloride<\/em><\/span><\/p>\n<table>\n<thead>\n<tr>\n<th><span style=\"color: #000000;\"><strong>Property<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>Value \/ Characteristic<\/strong><\/span><\/th>\n<th><span style=\"color: #000000;\"><strong>Notes\/Significance<\/strong><\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Molecular Formula<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">C\u2081\u2085H\u2082\u2084ClNO<\/span><\/td>\n<td><span style=\"color: #000000;\">Confirmed via HRMS, elemental analysis\u00a0<a style=\"color: #000000;\" href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/121230793\" target=\"_blank\" rel=\"noopener\">[1]<\/a>\u00a0[4].<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Molecular Weight<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">269.81 g\/mol<\/span><\/td>\n<td><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/121230793\" target=\"_blank\" rel=\"noopener\">[1]<\/a>\u00a0[4].<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>CAS Number<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">1797121-52-8<\/span><\/td>\n<td><span style=\"color: #000000;\">Unique identifier\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.medchemexpress.com\/3-methoxy-pce-hydrochloride.html?srsltid=AfmBOopW1EGbaimVILcmebkvdJzjn7iz3um9U-ewdn0ZIdf1fqvMbRM7\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Appearance<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">White to off-white crystalline solid<\/span><\/td>\n<td><span style=\"color: #000000;\">Typical for hydrochloride salts\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.medchemexpress.com\/3-methoxy-pce-hydrochloride.html?srsltid=AfmBOopW1EGbaimVILcmebkvdJzjn7iz3um9U-ewdn0ZIdf1fqvMbRM7\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Melting Point<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">Not definitively published (Analog: 3-MeO-PCP HCl ~204-205\u00b0C)<\/span><\/td>\n<td><span style=\"color: #000000;\">High melting point consistent with ionic solid.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Water Solubility<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">Moderate (HCl salt)<\/span><\/td>\n<td><span style=\"color: #000000;\">Sufficient for biological dissolution. Freebase: Low.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Solubility in Methanol<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">High (\u2265 1 mg\/mL)<\/span><\/td>\n<td><span style=\"color: #000000;\">Used for analytical standard solutions\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Estimated logP (Freebase)<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">~3.5-4.0 (Calculated)<\/span><\/td>\n<td><span style=\"color: #000000;\">Indicates moderate-high lipophilicity.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Estimated logD\u2087.\u2084 (HCl)<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">&lt; logP (Freebase)<\/span><\/td>\n<td><span style=\"color: #000000;\">Ionization reduces apparent lipophilicity at physiological pH.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>pKa (Amine)<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">Estimated ~8.5-9.5 (Typical for secondary alkyl amines)<\/span><\/td>\n<td><span style=\"color: #000000;\">Governs ionization state and partitioning.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000;\"><strong>Storage Conditions<\/strong><\/span><\/td>\n<td><span style=\"color: #000000;\">Room Temp. or below; protected from moisture &amp; light<\/span><\/td>\n<td><span style=\"color: #000000;\">Standard for stable hydrochloride salts\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.medchemexpress.com\/3-methoxy-pce-hydrochloride.html?srsltid=AfmBOopW1EGbaimVILcmebkvdJzjn7iz3um9U-ewdn0ZIdf1fqvMbRM7\" target=\"_blank\" rel=\"noopener\">[2]<\/a>\u00a0<a style=\"color: #000000;\" href=\"https:\/\/www.caymanchem.com\/product\/9001355\/3-methoxy-pce-(hydrochloride)?srsltid=AfmBOooZ6mQHwFl4-VamYVOasAkteiTSYe9SCsd18i1wJUezeIGpB4p9\" target=\"_blank\" rel=\"noopener\">[4]<\/a>.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>3-MeO-PCE buy\u00a03-MeO-PCE\u00a0online | Wholesale 3-MeO-PCE Buy 3-MeO-PCE online, (3-Methoxyeticyclidine) is a new designer substance of the dissociative class arylcyclohexylamine, which causes hallucinations.\u00a03-MeO-PCE&hellip;<\/p>","protected":false},"author":1,"featured_media":7920,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,3,9],"tags":[],"class_list":["post-7912","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dissociatives","category-new-chemicals","category-psychedelics"],"_links":{"self":[{"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/posts\/7912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/comments?post=7912"}],"version-history":[{"count":5,"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/posts\/7912\/revisions"}],"predecessor-version":[{"id":8337,"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/posts\/7912\/revisions\/8337"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/media\/7920"}],"wp:attachment":[{"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/media?parent=7912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/categories?post=7912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chemsaxis.com\/zh\/wp-json\/wp\/v2\/tags?post=7912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}