{"id":7523,"date":"2026-06-28T06:23:19","date_gmt":"2026-06-28T06:23:19","guid":{"rendered":"https:\/\/chemsaxis.com\/?p=7523"},"modified":"2026-06-29T07:09:44","modified_gmt":"2026-06-29T07:09:44","slug":"%d0%ba%d1%83%d0%bf%d0%b8%d1%82%d1%8c-%d0%bd%d0%be%d1%80%d1%82%d0%b8%d0%bb%d0%b8%d0%b4%d0%b8%d0%bd","status":"publish","type":"post","link":"https:\/\/chemsaxis.com\/ru\/buy-nortilidine\/","title":{"rendered":"\u041d\u043e\u0440\u0442\u0438\u043b\u0438\u0434\u0438\u043d"},"content":{"rendered":"
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Nortilidine – IN STOCK<\/strong><\/span><\/figcaption><\/figure>\n

Buy Nortilidine |Wholesale Nortilidine hydrochloride<\/h1>\n

Nortilidine is an opioid analgesic, a derivative of tilidine, with similar characteristics and effects on the body. This drug is a designer research substance, the opioid potency of Nortilidine is comparable to morphine.<\/span><\/p>\n

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(1R,2S)-nortilidine is an ethyl 2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate that is ent-dextilidine in which one of the methyl groups attached to the nitrogen is replaced by hydrogen. ent-Dextilidine is metabolised to (1R,2S)-nortilidine by the liver. It has a role as a drug metabolite and a NMDA receptor antagonist. It is an enantiomer of a (1S,2R)-nortilidine.<\/span><\/div>\n
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Nortilidine is classified as an opioid analgesic and is primarily derived from tilidine, which is administered as a prodrug. The compound’s classification falls under the categories of narcotics and psychoactive substances due to its effects on the central nervous system. It is recognized by various identifiers, including its IUPAC name, chemical formula C16H21NO2<\/span>C<\/span>16<\/span><\/span><\/span>\u200b<\/span><\/span><\/span><\/span><\/span>H<\/span>21<\/span><\/span><\/span>\u200b<\/span><\/span><\/span><\/span><\/span>N<\/span>O<\/span>2<\/span><\/span><\/span>\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>, and CAS number 259-349-0\u00a0<\/a>.\u00a0<\/span><\/span><\/div>\n<\/div>\n<\/div>\n

Nortilidine<\/b><\/sup>\u00a0is the major\u00a0active metabolite<\/a>\u00a0of\u00a0tilidine<\/a>. It is formed from tilidine by\u00a0demethylation<\/a>\u00a0in the\u00a0liver<\/a>. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine.<\/sup>\u00a0The (1R<\/i>,2S<\/i>)-isomer has\u00a0NMDA antagonist<\/a>\u00a0activity. The drug also acts as a\u00a0dopamine reuptake inhibitor<\/a>.<\/sup>\u00a0The reversed-ester of nortilidine is also known, as is the corresponding analogue with the cyclohexene ring replaced by cyclopentane,<\/sup> which have almost identical properties to nortilidine.<\/span><\/p>\n

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(+)-Nortilidine (CAS 37815-44-4): Procurement Baseline for Opioid Receptor Assays and Toxicological Workflows<\/span><\/h2>\n<\/div>\n
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(+)-Nortilidine is the primary, pharmacologically active N-demethylated metabolite of the opioid prodrug tilidine. In laboratory procurement, it is primarily sourced as an analytical reference standard for therapeutic drug monitoring and as a direct mu-opioid (MOP) receptor agonist for in vitro screening. Unlike its parent compound, (+)-Nortilidine does not require hepatic activation, making it the required baseline material for cell-based receptor assays, pharmacokinetic drug-drug interaction (DDI) modeling, and forensic LC-MS\/MS quantification workflows .<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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The Operational Cost of Substituting (+)-Nortilidine with Tilidine or Downstream Metabolites<\/span><\/h2>\n<\/div>\n
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Substituting (+)-Nortilidine with the parent prodrug tilidine in in vitro assays results in severe target under-quantification, as tilidine lacks direct MOP receptor activity without CYP3A4 and CYP2C19-mediated hepatic N-demethylation. Conversely, substitution with the secondary metabolite bisnortilidine fails because it lacks the necessary receptor binding affinity to model primary analgesic effects. Furthermore, utilizing racemic nortilidine instead of the enantiomerically pure (+)-Nortilidine introduces variable binding kinetics, compromising assay reproducibility in precise pharmacological profiling and forensic calibrations where absolute peak resolution is mandatory [1<\/a>].<\/span><\/p>\n

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References<\/span><\/h3>\n