{"id":8092,"date":"2026-07-07T17:51:25","date_gmt":"2026-07-07T17:51:25","guid":{"rendered":"https:\/\/chemsaxis.com\/?p=8092"},"modified":"2026-07-18T05:59:51","modified_gmt":"2026-07-18T05:59:51","slug":"buy-nitromethaqualone","status":"publish","type":"post","link":"https:\/\/chemsaxis.com\/it\/buy-nitromethaqualone\/","title":{"rendered":"Nitrometaqualone"},"content":{"rendered":"
\"Buy<\/a>
Nitromethaqualone<\/figcaption><\/figure>\n

Buy Nitromethaqualone online | Wholesale Nitromethaqualone<\/span><\/span><\/h1>\n

Buy Nitromethaqualone (CAS 340-52-3) is a synthetic quinazolinone derivative and a highly potent, nitro-substituted analogue of the sedative-hypnotic methaqualone . Structurally defined as 3-(2-methoxy-4-nitrophenyl)-2-methyl-4(3H)-quinazolinone, it serves as a critical analytical reference standard in forensic toxicology and a specialized model compound for metabolic research . While its clinical development was halted due to toxicity, its primary procurement value today lies in its role as a high-affinity positive allosteric modulator of GABA-A receptors and as an unequivocal standard for identifying clandestine quinazolinone derivatives in complex analytical matrices.\u00a0<\/span><\/p>\n

Price:<\/span><\/p>\n

Nitromethaqualone 10 g 140 $\u00a0Add to cart<\/b><\/a><\/span><\/strong><\/p>\n

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You can buy Nitromethaqualone<\/a> <\/span>online right now at Chemsaxis<\/strong><\/span><\/span>.<\/span><\/span><\/h2>\n

Nitromethaqualone is a designer drug intended for research and forensic analysis. Nitromethaqualone is produced in modern pharmaceutical laboratory in compliance with all quality standards.<\/span><\/p>\n

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Why Generic Substitution Fails for Nitromethaqualone Assays<\/h3>\n<\/div>\n
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Utilizing standard methaqualone or other halogenated analogues (such as mecloqualone) as a substitute in metabolic or forensic assays is fundamentally inadequate [1<\/a>]. Nitromethaqualone possesses a unique aromatic nitro group at the 4\u2032-position of the phenyl ring, which undergoes specific metabolic reduction to a mutagenic aniline derivative\u2014a toxicological pathway entirely absent in non-nitrated quinazolinones [2<\/a>]. Furthermore, its 10-fold higher binding potency at GABA-A receptors means that generic in-class substitutes cannot replicate its specific receptor binding kinetics, nor can they provide the distinct molecular mass and fragmentation profile required for accurate LC-MS\/MS forensic calibration.<\/p>\n<\/div>\n<\/div>\n

Storage conditions: in a cool and dry place,<\/span>
\nstorage for up to 2 years.<\/span><\/p>\n

\"Nitromethaqualone\"<\/a><\/span>
Nitromethaqualone<\/span><\/figcaption><\/figure>\n\n\n\n\n\n\n\n\n
Synonyms<\/strong><\/span><\/td>\n\n
    \n
  • \u00a0 Nitromethaqualone<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
IUPAC<\/strong><\/span><\/td>\n2-methyl-3-(2-methoxy-4-nitrophenyl)-4(3H)-quinazolinone<\/span><\/td>\n<\/tr>\n
Formula<\/strong><\/span><\/td>\nC16<\/small><\/sub>H13<\/small><\/sub>N3<\/small><\/sub>O4<\/small><\/sub><\/span><\/td>\n<\/tr>\n
Molecular weight<\/strong><\/span><\/td>\n311.29\u00a0g\u00b7mol\u22121<\/sup><\/span><\/td>\n<\/tr>\n
CAS<\/strong><\/span><\/td>\n340-52-3
\n<\/span><\/td>\n<\/tr>\n
Purity<\/strong><\/span><\/td>\n\u2265 98%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Best Research and Forensic Application Scenarios for Buying Nitromethaqualone <\/span><\/h2>\n<\/div>\n
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Forensic Toxicology and Seized Material Screening<\/h3>\n

Directly following from its distinct 311.3 g\/mol molecular weight and 226 nm UV maximum, nitromethaqualone is an indispensable analytical reference standard for forensic laboratories. It is utilized to calibrate LC-MS\/MS and GC-MS equipment, ensuring the unequivocal identification and quantification of this specific designer drug in complex clandestine mixtures, free from cross-reactivity with methaqualone.<\/p>\n

In Vitro Mutagenicity and Cytochrome P450 Metabolism Assays<\/h3>\n

Because its aromatic nitro group is specifically metabolized into a mutagenic aniline derivative, nitromethaqualone serves as a highly effective positive control in metabolic research[2<\/a>]. Toxicology labs procure this compound to study the enzymatic reduction pathways of nitro-aromatics and to validate assays detecting DNA-adduct formation, a use case impossible to fulfill with non-nitrated quinazolinones.<\/p>\n

High-Affinity GABA-A Receptor Modulation Studies<\/h3>\n

Leveraging its 10-fold higher potency compared to methaqualone, nitromethaqualone is utilized in neuropharmacological research to investigate extreme positive allosteric modulation of GABA-A receptors . Its high affinity allows researchers to conduct competitive binding assays at lower concentrations, thereby reducing the risk of solvent-induced artifacts in sensitive cell-based models.<\/p>\n

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Application Fit Matrix<\/h3>\n
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Application<\/div>\n
Selection Property<\/div>\n
Validation Focus<\/div>\n<\/div>\n
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Forensic identification of seized drugs<\/div>\n
Spectral fingerprint specificity (IR, NMR, GC\u2011MS)<\/div>\n
Confirm differentiation from positional isomers and quinazolinone analogues<\/div>\n<\/div>\n
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Nitro\u2011quinazolinone biotransformation research<\/div>\n
Metabolic pathway distinctiveness (nitro reduction)<\/div>\n
Verify formation of mutagenic aniline metabolite<\/div>\n<\/div>\n
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Quantitative assay calibration (LC\u2011MS\/MS, GC\u2011MS)<\/div>\n
Certified purity \u226598% and batch\u2011specific CoA<\/div>\n
Validate calibration accuracy and method linearity<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n
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References<\/h3>\n