Buy Etomidate online | Wholesale Etomidate Powder
Buy Etomidate (commercial name Amidate), which is a short-acting anesthetic agent which is administered intravenously to achieve anesthesia and sedation for medical purposes, e.g. for knuckle reduction or tracheal intubation, cardiac and electroconvulsive therapy. It is used as an anaesthetic because it has a rapid onset of action and is safe for cardiovascular disorders without causing a sharp fall in blood pressure and limited suppression of ventilation, it does not release histamine and protects against ischaemia of the myocardium and the brain. It is used in craniocerebral trauma because this anaesthetic is able to lower intracranial pressure and maintain normal arterial pressure, and it is also used before lobectomy in brain surgery.
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| Synonymes |
|
| UICPA | 1-[(1R)-1- |
| Formule | C14H16N2O2 |
| Poids moléculaire | 244.3 |
| CAS | 33125-97-2 |
| Apparence | |
| Pureté | ≥ 98 % |
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Optimal Application Scenarios for Etomidate
Use Case 1: Hypnotic Agent for Hemodynamically Compromised In Vivo Models
For inducing anesthesia in animal models with cardiovascular instability (e.g., models of hemorrhage, sepsis, or heart failure), Etomidate is a justified choice. Its minimal impact on blood pressure and heart rate compared to agents like Propofol ensures that the observed physiological data is attributable to the experimental condition, not the anesthetic.
Use Case 2: In Vitro and In Vivo Studies of GABA-A Receptor Subtype Function
As a highly selective positive modulator of GABA-A receptors containing β2 or β3 subunits, Etomidate serves as a precise pharmacological tool. It is ideal for experiments designed to isolate the function of these specific receptor subtypes, in contrast to less selective agents or those with different mechanisms like Ketamine.
Use Case 3: Procedures Requiring Rapid and Predictable Recovery
In longitudinal studies requiring multiple, brief anesthetic events with rapid recovery for behavioral or cognitive testing, Etomidate’s short context-sensitive half-time is a significant advantage. It allows for faster return to baseline compared to agents prone to accumulation, such as Midazolam.
Use Case 4: Pharmacological Model for Adrenocortical Suppression Studies
Due to its specific and potent inhibition of 11-beta-hydroxylase, Etomidate is the compound of choice for creating a transient, reversible model of adrenocortical suppression. This allows for the controlled study of the physiological consequences of acute cortisol deficiency.
References
- [1] Reynolds, D. S., Rosahl, T. W., Cirone, S. M., O’Meara, G. T., Ragozzino, L., Lovinger, D. M., … & Hadingham, K. L. (2003). Sedation and anesthesia mediated by distinct GABAA receptor isoforms. Journal of Neuroscience, 23(24), 8608-8617.
- [2] Belelli, D., Lambert, J. J., Peters, J. A., Wafford, K., & Hadingham, K. T. (1997). The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proceedings of the National Academy of Sciences, 94(20), 11031-11036.
- [3] Dishon, D. (2025). Comparative Evaluation of Propofol Versus Etomidate for Hemodynamic Stability during Induction and Endotracheal Intubation: A Randomized Study. Medical Science, 29, e402ms1321.
- [4] Rathore, G. S., & Singh, M. (2024). A COMPARATIVE STUDY OF PROPOFOL VERSUS ETOMIDATE AS INDUCTION AGENTS TO EVALUATE HAEMODYNAMIC CHANGES DURING ABDOMINAL SURGERY. International Journal of Academic Medicine and Pharmacy, 6(2), 1-6.
- [5] Upadhyay, A., & Aggarwal, S. (2023). Etomidate. In StatPearls. StatPearls Publishing.
- [6] Vogelsang, S., et al. (2021). Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats. International Journal of Molecular Sciences, 22(23), 12799.
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